In order to familiarize yourself with terms and definitions used by the Foundation and your future Collaborating Scientist colleagues, please find below a list of definitions that will assist you as you review this policy.

• AMRF Program: A working group that aims to develop basic and clinical diagnostic and therapeutic approaches for biologically connected diseases through interactive meetings, presentations and papers and by providing a forum for the development of Collaborations.

• Collaborating Institution: Any institution that has signed a Master Collaborative Research Agreement and its affiliates including, any hospital, health care, research, clinical, administrative, and instructional facility, including any center, department, institute and unit therein or affiliated therewith, owned or leased by, or gifted to, the Collaborating Institution.

• Collaborating Scientist: Any qualified physician, scientist or other personnel affiliated with a Collaborating Institution who agrees to work with the Foundation, for example by attending AMRF Program workshops or by serving as a Program Director or Investigator, at the request of the Foundation and with the consent of the Collaborating Institution with which the individual is affiliated.

• Collaboration: A group of three or more integrated and coordinated Component Projects that inform and enrich one another around a specific set of scientific aims.

• Collaborating Liaison: The Collaborating Scientist who provides administrative coordination for a Collaboration and serves as the liaison for that Collaboration with the Foundation and between participating Study Sites.

• Collaborating Liaison Application: The application, in a form to be determined by the Foundation, submitted by a Collaboration Liaison to describe the objectives of the Collaboration and to identify the Principal Investigators who will be submitting the applicable Component Project Applications.

• Component Project: A Research Study that is proposed by a Collaborating Scientist to be incorporated into a Collaboration and is undertaken pursuant to an MCRA Addendum.

• Component Project Application: The application, on a form to be determined by the Foundation, submitted by a potential Principal Investigator describing her Study Site's anticipated participation in a proposed Component Project, her qualifications, and the Site Budget.

• Discovery Management Agreement: The companion agreement to the Master Collaborative Research Agreement setting forth the roles and responsibilities of Collaborating Institutions and the Foundation to cooperate on the commercialization of biomedical innovations arising from Collaborations.

• Invited Guest: A non-Collaborating Scientist invited by the Foundation to attend an AMRF Program workshop.

• Master Collaborative Research Agreement Addendum or MCRA Addendum: The agreement between the Foundation and a Study Site where a Component Project is conducted setting forth the general rights and responsibilities of the parties with respect to conducting a Component Project.

• Milestones: The pre-identified benchmarks established by a Principal Investigator and used by the Foundation to evaluate requests for re-approval of Component Project Applications at the end of each annual funding period.

• Platform: A specialized kind of Innovation Tool that involves a methodology, biomedical skill or process, laboratory or other specialized medical service provided by one or more Collaborating Scientists, Research Team Members or third-parties and funded by the Foundation to provide expertise to Collaborations (e.g., electron microscopy, genomic array analysis, high throughput screens) pursuant to a Platform Services Agreement. In certain specific cases, a Collaboration could also be formed to explore how to customize an existing Platform to provide new applications for one or more Programs.

• Principal Investigator: The Collaborating Scientist who leads a Component Project and serves as the principal investigator for any Component Project research-related activities undertaken at her Study Site in connection with that Component Project. In most cases, but not all, this will also be the Collaborating Scientist who initially proposed that the Component Project be part of the Collaboration and submitted the Component Project Application.

• Program Director: A Collaborating Scientist who coordinates and administers an AMRF Program.

• Program Manager: The Foundation employee who manages the day-to-day operations of a Program.

• Research Team Member: Any employee, affiliate, agent, independent contractor, volunteer, student, or other individual associated with a Collaborating Institution who assists on a Component Project.

• Science Officer: The Foundation employee who facilitates the growth and development of new and existing Programs.

• Sub-Investigator: A Research Team Member who serves as an investigator but is not the Principal Investigator on a Component Project. A Sub-Investigator can be a Collaborating Scientist or an individual who is not yet a Collaborating Scientist but whose participation has been approved by the Foundation.



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