The mission of the Foundation is to foster highly interactive and collaborative inter-institutional research designed to accelerate progress towards testable interventions for human disease. The fundamental approach to the development of a new AMRF Program should be to optimize potential synergies that can be obtained from an open and energetic collaboration among outstanding basic and clinical investigators.

A new AMRF Program ought to identify an important set of health-related problems that offers opportunities for a collaboration to prevent, manage or cure and offer a forum to:
a) examine the conceptual bases about the evolution of a particular disease or a set of diseases that may share common biological denominators;
b) identify impediments to the most productive understanding of disease mechanisms and the best pathways to discover cures;
c) consider (i) the biases that permeate current scientific and clinical perceptions and impede innovation; (ii) the known mechanisms that appear to contribute; (iii) potential alternative mechanisms; (iv) the aspects of these basic mechanisms and clinical phenotypes that are uncertain or unknown; (v) which processes relevant to development, maintenance and progression of disease may serve as the focus for a collaborative approach to problem solving that leads to disease modification or cure; (vi) the rate-limiting steps for achieving the ability to manipulate the key processes involved in the disease; (vii) the scientific tools and experimental approaches required for a successful new AMRF Program; (viii) whether available animal models are sufficient for testing existing or novel translational strategies; (ix) what human pathologic specimens are required to explore disease mechanisms at the organism, cell and molecular levels; and (x) the spectrum of scientific pursuits, such as gene expression and other "-omics," signaling profiles, cell receptors, biophysical properties, immunological components, in vitro and in vivo labeling and imaging approaches, behavioral measures, and clinical phenotypes that are relevant to the proposed AMRF Program.

The Foundation does not formally seek proposals for new AMRF Programs but welcomes suggestions. If you are interested in suggesting a new AMRF Program, please submit a 1-2 page overview at This proposal should describe how the Collaborative Model is specifically well-tailored to exploring basic and clinical diagnostic and therapeutic approaches for the biologically connected diseases.

An unsolicited proposal will be considered by the Foundation. If the Foundation believes the suggestion may have merit, the Science Officer will discuss the proposal with you and will consult other experts to determine if the proposal should lead to a new AMRF Program.

Once the Foundation approves a new AMRF Program, the Foundation will develop an initial list of potential Collaborating Scientists and scientific goals. Discussions among these potential Collaborating Scientists by Web-based interactions precede the first workshop.

The initial workshop aims to introduce the skills and studies of each Collaborating Scientist that could be relevant to the eventual goals of the AMRF Program. It should provide an atmosphere where Collaborating Scientists are encouraged to try to make each other's ideas work and to put big and provocative ideas on the table. The AMRF Program will develop a consensus about the questions that initial Collaborations should address, although long-term basic and clinical research aims and strategies will also be discussed.