{"id":144,"date":"2021-04-20T22:06:51","date_gmt":"2021-04-20T22:06:51","guid":{"rendered":"http:\/\/localhost\/amrf\/wp\/?page_id=144"},"modified":"2022-11-11T19:40:38","modified_gmt":"2022-11-11T19:40:38","slug":"amrf-programs","status":"publish","type":"page","link":"https:\/\/www.adelsonfoundation.org\/AMRF\/amrf-programs\/","title":{"rendered":"AMRF Programs"},"content":{"rendered":"\n<section id=\"banner-block_608039e4963bc\" class=\"block block--banner block_align_text_left\">\n\t<style>#banner-block_608039e4963bc {--block_wp_padding_top: 1vw;--block_wp_padding_bottom: 1vw;}#banner-block_608039e4963bc::before {background-color: #94b5c1;}#banner-block_608039e4963bc .block__title {color: #ffffff;}<\/style>\t\t<div class=\"block__content banner__content container \">\n\t\t<h1 class=\"block__title banner__title section_title \">AMRF Investigational Programs<\/h1>\t\t\t\t\t<\/div>\n<\/section>\n\n\n<section id=\"boxes-block_60803984963b8\" class=\"block block--boxes block_align_text_left block--has_background_image\">\n    <style>#boxes-block_60803984963b8 {color: #ffffff;}#boxes-block_60803984963b8::before {background-color: #000000;}#boxes-block_60803984963b8 .block__subtitle {color: #ffffff;}<\/style>    <div class=\"block__background_image overlay\"><img loading=\"lazy\" decoding=\"async\" width=\"1402\" height=\"1172\" src=\"https:\/\/www.adelsonfoundation.org\/AMRF\/wp-content\/uploads\/2021\/04\/pexels-photo-2280549.jpg\" class=\"attachment-full size-full\" alt=\"\" srcset=\"https:\/\/www.adelsonfoundation.org\/AMRF\/wp-content\/uploads\/2021\/04\/pexels-photo-2280549.jpg 1402w, https:\/\/www.adelsonfoundation.org\/AMRF\/wp-content\/uploads\/2021\/04\/pexels-photo-2280549-300x251.jpg 300w, https:\/\/www.adelsonfoundation.org\/AMRF\/wp-content\/uploads\/2021\/04\/pexels-photo-2280549-1024x856.jpg 1024w, https:\/\/www.adelsonfoundation.org\/AMRF\/wp-content\/uploads\/2021\/04\/pexels-photo-2280549-768x642.jpg 768w\" sizes=\"auto, (max-width: 1402px) 100vw, 1402px\" \/><\/div>    <div class=\"block__content boxes__content container \">\n        <div class=\"boxes\">\n            \n                <div class=\"box\" style=\"background-color: #237A99;\">\n                                                <h3 class=\"block__subtitle boxes__title   onview\">Ubiquitin Proteasome Pathway<\/h3>                                                <div class=\"block__text boxes__text  onview \">Protein ubiquitination, similar to protein phosphorylation, regulates many of the intracellular processes that are critical for the survival of malignant cells. AMRF believes that a deeper understanding of protein ubiquitination will lead to new therapies for malignancies, immunological and inflammatory diseases, and degenerative diseases of the nervous system. <\/div>                <\/div>\n            \n                <div class=\"box\" style=\"background-color: #237A99;\">\n                                                <h3 class=\"block__subtitle boxes__title   onview\">Ovarian Cancer<\/h3>                                                <div class=\"block__text boxes__text  onview \">Basic research has shown that within specific cancer types such as breast cancer or lung cancer, many subtypes exist that require distinctive therapeutic approaches. The AMRF Ovarian Cancer Research program believes that we must learn more about the various types of genetic, epigenetic, and molecular alterations that have occurred in cancerous tissues, and translate the most promising scientific and therapeutic leads into near-term clinical trials that will improve outcomes for ovarian cancer (OvCa) patients. <\/div>                <\/div>\n            \n                <div class=\"box\" style=\"background-color: #237A99;\">\n                                                <h3 class=\"block__subtitle boxes__title   onview\"> Melanoma<\/h3>                                                <div class=\"block__text boxes__text  onview \">Melanoma therapy has undergone a revolution during the past 10 years, consisting of breakthroughs in both targeted and immune therapies. The AMRF Melanoma investigators have contributed importantly to this revolution and are building on these successes to identify mechanisms of resistance to these treatments, elucidate strategies to overcome that resistance, discover tests that predict treatment efficacy, and understand\/minimize treatment side effects in order to optimize patient quality of life and overall survival.<\/div>                <\/div>\n            \n                <div class=\"box\" style=\"background-color: #237A99;\">\n                                                <h3 class=\"block__subtitle boxes__title   onview\"> Multiple Myeloma<\/h3>                                                <div class=\"block__text boxes__text  onview \">Our immune system has evolved to protect us from diseases; however, multiple myeloma is a cancer that starts in the immune system and can be life threatening. The AMRF Multiple Myeloma Program aims to identify early changes in the immune system that lead to myeloma and develop treatment strategies to prevent the lethality of the disease. Understanding, diagnosing and treating the disease through scientific discovery that can translate into clinical practice is the core organizing principle of the myeloma program.<\/div>                <\/div>\n            \n                <div class=\"box\" style=\"background-color: #237A99;\">\n                                                <h3 class=\"block__subtitle boxes__title   onview\">Neural Repair in Brain Injury and Disease<\/h3>                                                <div class=\"block__text boxes__text  onview \">The limited recovery in brain injury and disease means that stroke and traumatic brain injury, and their attendant loss of neurons, myelin and white matter, are leading causes of adult neurological disability. Mechanisms of circuit reorganization and recovery after brain injury exist, and these might serve as targets for the development of new therapies to further improve recovery. The AMRF Neural Repair in Brain Injury and Disease program focuses on identifying mechanisms of repair and cell replacement after stroke and other injuries, and to use that understanding to develop new treatment strategies for disorders of brain cell injury and loss.<\/div>                <\/div>\n            \n                <div class=\"box\" style=\"background-color: #237A99;\">\n                                                <h3 class=\"block__subtitle boxes__title   onview\"> Peripheral Neuropathy and PNS Nerve Regeneration<\/h3>                                                <div class=\"block__text boxes__text  onview \">There are currently no therapies that promote functional recovery after peripheral nerve injury or that maintain nerve function in peripheral neuropathies. The AMRF Peripheral Neuropathy and PNS Nerve Regeneration group is working to identify mechanisms of axon growth and survival, remyelination, and axoglial interactions. Our goal is to discover mechanisms that promote regeneration and remyelination, that protect axons from damage and degeneration, to validate these as viable therapeutic targets, and then translate these discoveries into new treatments.<\/div>                <\/div>\n            \n                <div class=\"box\" style=\"background-color: #237A99;\">\n                                                <h3 class=\"block__subtitle boxes__title   onview\"> Spinal Cord Injury and CNS Nerve Regeneration<\/h3>                                                <div class=\"block__text boxes__text  onview \">The inability of the injured spinal cord or brain to repair themselves and restore function after injury has been recognized for millennia. The AMRF Spinal Cord Injury and CNS Nerve Regeneration collaboration focuses on identifying cellular interactions and mechanisms that control the re-growth and targeting of nerve fibers after injury to the spinal cord or brain. Understanding these interactions and mechanisms will allow us to develop drugs, genetic manipulations and cell therapies to improve repair, leading to a new generation of therapies for spinal cord and brain injuries and other neurological disorders.<\/div>                <\/div>\n            \n                <div class=\"box\" style=\"background-color: #237A99;\">\n                                                <h3 class=\"block__subtitle boxes__title   onview\"> Protection and Regeneration in Multiple Sclerosis<\/h3>                                                <div class=\"block__text boxes__text  onview \">Despite advances in treating acute multiple sclerosis (MS), we lack treatments for critical aspects of MS that contribute to clinical progression. Stopping progressive MS requires a precise understanding of how the relationship between nerve cells and the cells that make myelin is disrupted. The AMRF MS group focuses on dynamic analysis of MS and its animal models, defining pathways used for communication between nerve cells and myelin, interrogating interactions between the nervous and immune systems, and identifying therapeutic approaches to enhance repair and forestall, if not reverse, progressive MS.<\/div>                <\/div>\n                    <\/div>\n    <\/div>\n<\/section>\n\n\n<section id=\"team-block_615fee6ce60d3\" class=\"block block--team block_align_text_left block--has_background_image\">\n\t<style>#team-block_615fee6ce60d3 {color: #ffffff;--block_wp_padding_top: 2.143vw;--block_wp_padding_bottom: 3.071vw;}#team-block_615fee6ce60d3::before {background-color: #237a99;}#team-block_615fee6ce60d3 .block__title {color: #ffffff;}#team-block_615fee6ce60d3 .block__subtitle {color: #ffffff;}<\/style>\t<div class=\"block__background_image \"><img loading=\"lazy\" decoding=\"async\" width=\"1400\" height=\"1180\" src=\"https:\/\/www.adelsonfoundation.org\/AMRF\/wp-content\/uploads\/2021\/04\/shape4.svg\" class=\"attachment-full size-full\" alt=\"\" \/><\/div>\t<div class=\"block__content team__content container \">\n\t\t<h2 class=\"block__title team__title section_title \">AMRF Funded Investigators<\/h2>\t\t<div class=\"block__text team__text \"><p style=\"text-align: center;\">AMRF recruits cross-disciplinary teams of leading scientists who collaborate to pursue pioneering research on key areas of need.<\/p>\n<\/div>\t\t<div class=\"team__team-wrapper\"><div class=\"team__person \"><div class=\"team__person__image-wrapper\" ><img loading=\"lazy\" decoding=\"async\" width=\"251\" height=\"249\" src=\"https:\/\/www.adelsonfoundation.org\/AMRF\/wp-content\/uploads\/2021\/04\/2.jpg\" class=\"attachment-full size-full wp-post-image\" alt=\"\" srcset=\"https:\/\/www.adelsonfoundation.org\/AMRF\/wp-content\/uploads\/2021\/04\/2.jpg 251w, https:\/\/www.adelsonfoundation.org\/AMRF\/wp-content\/uploads\/2021\/04\/2-150x150.jpg 150w\" sizes=\"auto, (max-width: 251px) 100vw, 251px\" \/><\/div><div class=\"team__person__content\"><div><h3 class=\"team__person__name\">Joan Brugge, PhD<\/h3><p class=\"team__person__title\">Ovarian Cancer<\/p><\/div><ul class=\"team__person__qualifications\"><li>Director, Ludwig Center at Harvard Medical School <\/li><li>Professor of Cell Biology at Harvard Medical School<\/li><\/ul><\/div><\/div><div class=\"team__person \"><div class=\"team__person__image-wrapper\" ><img loading=\"lazy\" decoding=\"async\" width=\"251\" height=\"249\" src=\"https:\/\/www.adelsonfoundation.org\/AMRF\/wp-content\/uploads\/2021\/04\/1.jpg\" class=\"attachment-full size-full wp-post-image\" alt=\"\" srcset=\"https:\/\/www.adelsonfoundation.org\/AMRF\/wp-content\/uploads\/2021\/04\/1.jpg 251w, https:\/\/www.adelsonfoundation.org\/AMRF\/wp-content\/uploads\/2021\/04\/1-150x150.jpg 150w\" sizes=\"auto, (max-width: 251px) 100vw, 251px\" \/><\/div><div class=\"team__person__content\"><div><h3 class=\"team__person__name\">Stanley Thomas Carmichael, MD, PhD<\/h3><p class=\"team__person__title\">Neural Repair in Brain Injury and Disease<\/p><\/div><ul class=\"team__person__qualifications\"><li>Professor and Chair<\/li><li>Frances Stark Chair<\/li><li>Department of Neurology<\/li><li>David Geffen School of Medicine at UCLA<\/li><li>Co-Director UCLA Broad Stem Cell Research Center<\/li><\/ul><\/div><\/div><div class=\"team__person \"><div class=\"team__person__image-wrapper\" ><img loading=\"lazy\" decoding=\"async\" width=\"252\" height=\"249\" src=\"https:\/\/www.adelsonfoundation.org\/AMRF\/wp-content\/uploads\/2021\/04\/3.jpg\" class=\"attachment-full size-full wp-post-image\" alt=\"\" \/><\/div><div class=\"team__person__content\"><div><h3 class=\"team__person__name\">Aaron Ciechanover, MD, DSc<\/h3><p class=\"team__person__title\">Ubiquitin-Regulated Pathways for Cancer Therapeutics<\/p><\/div><ul class=\"team__person__qualifications\"><li>Biologist, Faculty of Medicine, Technion-Israel Institute of Technology <\/li><li>Haifa, Israel<\/li><\/ul><\/div><\/div><\/div>\t\t<div class=\"team__block_button_wrap \"><a class=\"btn btn--primary\" href=\"https:\/\/www.adelsonfoundation.org\/AMRF\/amrf-investigators\/\" target=\"_self\">Meet the Investigators<\/a><\/div>\t<\/div>\n<\/section>\n\n\n<section id=\"newsletter-block_608046b1ba94b\" class=\"block block--newsletter block_align_text_left\">\n\t<style>#newsletter-block_608046b1ba94b {--block_wp_padding_top: 1.714vw;--block_wp_padding_bottom: 1.714vw;}#newsletter-block_608046b1ba94b::before {background-color: #94B5C1;}#newsletter-block_608046b1ba94b .block__title {color: #ffffff;}<\/style>\t\t<div class=\"block__content newsletter__content container \">\n\t\t<h2 class=\"block__title section_title \">Sign Up For Foundation Updates and News<\/h2>\t\t<div class=\"newsletter__form-wrapper \">\n<div 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