News

“ANGPTL4 promotes the progression of cutaneous melanoma to brain metastasis.”

Izraely, S., S. Ben-Menachem, O. Sagi-Assif, T. Meshel, D. M. Marzese, S. Ohe, I. Zubrilov, M. Pasmanik-Chor, D. S. B. Hoon and I. P. Witz
Oncotarget
, 2017.

“CCR4 is a determinant of melanoma brain metastasis.”

Klein, A., O. Sagi-Assif, T. Meshel, A. Telerman, S. Izraely, S. Ben-Menachem, J. Bayry, D. M. Marzese, S. Ohe, D. S. B. Hoon, N. Erez and I. P. Witz
Oncotarget
, 2017.

“A Comprehensive Patient-Derived Xenograft Collection Representing the Heterogeneity of Melanoma.”

Krepler, C., K. Sproesser, P. Brafford, M. Beqiri, B. Garman, M. Xiao, B. Shannan, A. Watters, M. Perego, G. Zhang, A. Vultur, X. Yin, Q. Liu, I. N. Anastopoulos, B. Wubbenhorst, M. A. Wilson, W. Xu, G. Karakousis, M. Feldman, X. Xu, R. Amaravadi, T. C. Gangadhar, D. E. Elder, L. E. Haydu, J. A. Wargo, M. A. Davies, Y. Lu, G. B. Mills, D. T. Frederick, M. Barzily-Rokni, K. T. Flaherty, D. S. Hoon, M. Guarino, J. J. Bennett, R. W. Ryan, N. J. Petrelli, C. L. Shields, M. Terai, T. Sato, A. E. Aplin, A. Roesch, D. Darr, S. Angus, R. Kumar, E. Halilovic, G. Caponigro, S. Jeay, J. Wuerthner, A. Walter, M. Ocker, M. B. Boxer, L. Schuchter, K. L. Nathanson and M. Herlyn
Cell Rep
, 2017.

“Inhibition of stress-inducible HSP70 impairs mitochondrial proteostasis and function.”

Leu, J. I., T. Barnoud, G. Zhang, T. Tian, Z. Wei, M. Herlyn, M. E. Murphy and D. L. George
Oncotarget
, 2017.

“Signaling and Immune Regulation in Melanoma Development and Responses to Therapy.”

Lin, W. M. and D. E. Fisher
Annu Rev Pathol
, 2017.

“PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas.”

Lu, H., S. Liu, G. Zhang, W. Bin, Y. Zhu, D. T. Frederick, Y. Hu, W. Zhong, S. Randell, N. Sadek, W. Zhang, G. Chen, C. Cheng, J. Zeng, L. W. Wu, J. Zhang, X. Liu, W. Xu, C. Krepler, K. Sproesser, M. Xiao, B. Miao, J. Liu, C. D. Song, J. Y. Liu, G. C. Karakousis, L. M. Schuchter, Y. Lu, G. Mills, Y. Cong, J. Chernoff, J. Guo, G. M. Boland, R. J. Sullivan, Z. Wei, J. Field, R. K. Amaravadi, K. T. Flaherty, M. Herlyn, X. Xu and W. Guo
Nature
, 2017.

“A UV-Independent Topical Small-Molecule Approach for Melanin Production in Human Skin.”

Mujahid, N., Y. Liang, R. Murakami, H. G. Choi, A. S. Dobry, J. Wang, Y. Suita, Q. Y. Weng, J. Allouche, L. V. Kemeny, A. L. Hermann, E. M. Roider, N. S. Gray and D. E. Fisher
Cell Rep
, 2017.

“ATG5 Mediates a Positive Feedback Loop between Wnt Signaling and Autophagy in Melanoma.”

Ndoye, A., A. Budina-Kolomets, C. H. Kugel, 3rd, M. R. Webster, A. Kaur, R. Behera, V. W. Rebecca, L. Li, P. A. Brafford, Q. Liu, Y. N. V. Gopal, M. A. Davies, G. B. Mills, X. Xu, H. Wu, M. Herlyn, M. C. Nicastri, J. D. Winkler, M. S. Soengas, R. K. Amaravadi, M. E. Murphy and A. T. Weeraratna
Cancer Res
, 2017.

“Trends in hepatocyte growth factor, insulin-like growth factor 1, thyroid-stimulating hormone, and leptin expression levels in uveal melanoma patient serum and tumor tissues: correlation to disease progression.”

Oba, J., B. Esmaeli, J. A. Ellerhorst, G. R. Lyons, D. R. Milton, W. L. Wang, M. P. Macedo, A. J. Lazar, E. A. Grimm and C. Chattopadhyay
Melanoma Res
, 2017.

“Non-Euclidean phasor analysis for quantification of oxidative stress in ex vivo human skin exposed to sun filters using fluorescence lifetime imaging microscopy.”

Osseiran, S., E. M. Roider, H. Wang, Y. Suita, M. Murphy, D. E. Fisher and C. L. Evans
J Biomed Opt
, 2017.

“Adoptive cell therapy: past, present and future.”

Cohen, J. E., S. Merims, S. Frank, R. Engelstein, T. Peretz and M. Lotem
Immunotherapy
, 2017.

“Melanoma in 2017: Moving treatments earlier to move further forwards.”

Davies, M. A. and K. T. Flaherty
Nat Rev Clin Oncol
, 2017.

“Adaptive resistance of melanoma cells to RAF inhibition via reversible induction of a slowly dividing de-differentiated state.”

Fallahi-Sichani, M., V. Becker, B. Izar, G. J. Baker, J. R. Lin, S. A. Boswell, P. Shah, A. Rotem, L. A. Garraway and P. K. Sorger
Mol Syst Biol
, 2017.

“Completion Dissection or Observation for Sentinel-Node Metastasis in Melanoma.”

Faries, M. B., J. F. Thompson, A. J. Cochran, R. H. Andtbacka, N. Mozzillo, J. S. Zager, T. Jahkola, T. L. Bowles, A. Testori, P. D. Beitsch, H. J. Hoekstra, M. Moncrieff, C. Ingvar, M. Wouters, M. S. Sabel, E. A. Levine, D. Agnese, M. Henderson, R. Dummer, C. R. Rossi, R. I. Neves, S. D. Trocha, F. Wright, D. R. Byrd, M. Matter, E. Hsueh, A. MacKenzie-Ross, D. B. Johnson, P. Terheyden, A. C. Berger, T. L. Huston, J. D. Wayne, B. M. Smithers, H. B. Neuman, S. Schneebaum, J. E. Gershenwald, C. E. Ariyan, D. C. Desai, L. Jacobs, K. M. McMasters, A. Gesierich, P. Hersey, S. D. Bines, J. M. Kane, R. J. Barth, G. McKinnon, J. M. Farma, E. Schultz, S. Vidal-Sicart, R. A. Hoefer, J. M. Lewis, R. Scheri, M. C. Kelley, O. E. Nieweg, R. D. Noyes, D. S. B. Hoon, H. J. Wang, D. A. Elashoff and R. M. Elashoff
N Engl J Med
, 2017.

“Feasibility of ultra-high-throughput functional screening of melanoma biopsies for discovery of novel cancer drug combinations.”

Friedman, A. A., Y. Xia, L. Trippa, L. P. Le, V. Igras, D. T. Frederick, J. A. Wargo, K. K. Tanabe, D. P. Lawrence, D. S. Neuberg, K. T. Flaherty and D. Fisher
Clin Cancer Res
, 2017.

“Genetic and Genomic Characterization of 462 Melanoma Patient-Derived Xenografts, Tumor Biopsies, and Cell Lines.”

Garman, B., I. N. Anastopoulos, C. Krepler, P. Brafford, K. Sproesser, Y. Jiang, B. Wubbenhorst, R. Amaravadi, J. Bennett, M. Beqiri, D. Elder, K. T. Flaherty, D. T. Frederick, T. C. Gangadhar, M. Guarino, D. Hoon, G. Karakousis, Q. Liu, N. Mitra, N. J. Petrelli, L. Schuchter, B. Shannan, C. L. Shields, J. Wargo, B. Wenz, M. A. Wilson, M. Xiao, W. Xu, X. Xu, X. Yin, N. R. Zhang, M. A. Davies, M. Herlyn and K. L. Nathanson
Cell Rep
, 2017.