News

“Detecting Demyelination by PET: The Lesion as Imaging Target.”

Brugarolas, P., D. S. Reich and B. Popko
Mol Imaging
, 2018.

“Development of a PET radioligand for potassium channels to image CNS demyelination.”

Brugarolas, P., J. E. Sanchez-Rodriguez, H. M. Tsai, F. Basuli, S. H. Cheng, X. Zhang, A. V. Caprariello, J. J. Lacroix, R. Freifelder, D. Murali, O. DeJesus, R. H. Miller, R. E. Swenson, C. T. Chen, P. Herscovitch, D. S. Reich, F. Bezanilla and B. Popko
Sci Rep
, 2018.

“Defective cholesterol clearance limits remyelination in the aged central nervous system.”

Cantuti-Castelvetri, L., D. Fitzner, M. Bosch-Queralt, M. T. Weil, M. Su, P. Sen, T. Ruhwedel, M. Mitkovski, G. Trendelenburg, D. Lutjohann, W. Mobius and M. Simons
Science
, 2018.

“Cholesterol crystals impede nerve repair.”

Chen, Y. and B. Popko
Science
, 2018.

“Phosphorylation State of ZFP24 Controls Oligodendrocyte Differentiation.”

Elbaz, B., J. D. Aaker, S. Isaac, A. Kolarzyk, P. Brugarolas, A. Eden and B. Popko
Cell Rep
, 2018.

“Myelin remodeling through experience-dependent oligodendrogenesis in the adult somatosensory cortex.”

Hughes, E. G., J. L. Orthmann-Murphy, A. J. Langseth and D. E. Bergles
Nat Neurosci
, 2018.

“Oligodendrocytes control potassium accumulation in white matter and seizure susceptibility.”

Larson, V. A., Y. Mironova, K. G. Vanderpool, A. Waisman, J. E. Rash, A. Agarwal and D. E. Bergles
Elife
, 2018.

“A Subpopulation of Foxj1-Expressing, Nonmyelinating Schwann Cells of the Peripheral Nervous System Contribute to Schwann Cell Remyelination in the Central Nervous System.”

Ma, D., B. Wang, M. Zawadzka, G. Gonzalez, Z. Wu, B. Yu, E. L. Rawlins, R. J. M. Franklin and C. Zhao
J Neurosci
, 2018.

“Initiation of CNS Myelination in the Optic Nerve Is Dependent on Axon Caliber.”

Mayoral, S. R., A. Etxeberria, Y. A. Shen and J. R. Chan
Cell Rep
, 2018.

“Oligodendrocyte-encoded Kir4.1 function is required for axonal integrity.”

Schirmer, L., W. Mobius, C. Zhao, A. Cruz-Herranz, L. Ben Haim, C. Cordano, L. R. Shiow, K. W. Kelley, B. Sadowski, G. Timmons, A. K. Probstel, J. N. Wright, J. H. Sin, M. Devereux, D. E. Morrison, S. M. Chang, K. Sabeur, A. J. Green, K. A. Nave, R. J. Franklin and D. H. Rowitch
Elife
, 2018.

“The ubiquitin-proteasome system: A potential therapeutic target for heart failure.”

Barac, Y. D., F. Emrich, E. Krutzwakd-Josefson, S. Schrepfer, L. C. Sampaio, J. T. Willerson, R. C. Robbins, A. Ciechanover, F. W. Mohr, D. Aravot and D. A. Taylor
J Heart Lung Transplant
, 2017.

“Targeting tryptophan catabolic kynurenine pathway enhances antitumor immunity and cytotoxicity in multiple myeloma.”

Ray, A., Y. Song, T. Du, Y. T. Tai, D. Chauhan and K. C. Anderson
Leukemia
, 2020.

“Activating KRAS, NRAS, and BRAF mutants enhance proteasome capacity and reduce endoplasmic reticulum stress in multiple myeloma.”

Shirazi, F., R. J. Jones, R. K. Singh, J. Zou, I. Kuiatse, Z. Berkova, H. Wang, H. C. Lee, S. Hong, L. Dick, N. Chattopadhyay and R. Z. Orlowski
Proc Natl Acad Sci U S A
, 2020.

“A novel BCMA PBD-ADC with ATM/ATR/WEE1 inhibitors or bortezomib induce synergistic lethality in multiple myeloma.”

Xing, L., L. Lin, T. Yu, Y. Li, S. F. Cho, J. Liu, K. Wen, P. A. Hsieh, K. Kinneer, N. Munshi, K. C. Anderson and Y. T. Tai
Leukemia
, 2020.

“Single-cell RNA sequencing reveals compromised immune microenvironment in precursor stages of multiple myeloma.”

Zavidij, O., N. J. Haradhvala, T. H. Mouhieddine, R. Sklavenitis-Pistofidis, S. Cai, M. Reidy, M. Rahmat, A. Flaifel, B. Ferland, N. K. Su, M. P. Agius, J. Park, S. Manier, M. Bustoros, D. Huynh, M. Capelletti, B. Berrios, C. J. Liu, M. X. He, E. Braggio, R. Fonseca, Y. Maruvka, J. L. Guerriero, M. Goldman, E. van Allen, S. A. McCarroll, J. Azzi, G. Getz and I. M. Ghobrial
Nat Cancer
, 2020.

“The novel protein homeostatic modulator BTX306 is active in myeloma and overcomes bortezomib and lenalidomide resistance.”

Zou, J., R. J. Jones, H. Wang, I. Kuiatse, F. Shirazi, E. E. Manasanch, H. C. Lee, R. Sullivan, L. Fung, N. Richard, P. Erdman, E. Torres, D. Hecht, I. Lam, B. McElwee, A. H. Chourasia, K. W. H. Chan, F. Mercurio, D. I. Stirling and R. Z. Orlowski
J Mol Med (Berl)
, 2020.