News

“Cancer therapies based on targeted protein degradation – lessons learned with lenalidomide.”

Jan, M., A. S. Sperling and B. L. Ebert
Nat Rev Clin Oncol
, 2021.

“Targeting ubiquitin-specific protease-7 in plasmacytoid dendritic cells triggers anti-myeloma immunity.”

Ray, A., T. Du, Y. Song, S. J. Buhrlage, D. Chauhan and K. C. Anderson
Leukemia
, 2021.

“Identification of novel anti-tumor therapeutic target via proteomic characterization of ubiquitin receptor ADRM1/Rpn13.”

Song, Y., T. Du, A. Ray, K. Chauhan, M. Samur, N. Munshi, D. Chauhan and K. C. Anderson
Blood Cancer J
, 2021.

“BCAS1 expression defines a population of early myelinating oligodendrocytes in multiple sclerosis lesions.”

Fard, M. K., F. van der Meer, P. Sanchez, L. Cantuti-Castelvetri, S. Mandad, S. Jakel, E. F. Fornasiero, S. Schmitt, M. Ehrlich, L. Starost, T. Kuhlmann, C. Sergiou, V. Schultz, C. Wrzos, W. Bruck, H. Urlaub, L. Dimou, C. Stadelmann and M. Simons
Sci Transl Med
, 2017.

“Preclinical validation of Alpha-Enolase (ENO1) as a novel immunometabolic target in multiple myeloma.”

Ray, A., Y. Song, T. Du, D. Chauhan and K. C. Anderson
Oncogene
, 2020.

“SARS-CoV-2 in multiple myeloma: initial observation and management.”

Manasanch, E. E., V. Mulanovich, J. G. Manzano, M. S. Gaeta, M. Becnel, G. P. Kaufman, H. C. Lee, B. Amini, S. K. Thomas, S. P. Iyer, D. M. Weber, Z. Berkova, C. R. Flowers, R. Z. Orlowski and K. K. Patel
Leuk Lymphoma
, 2020.

“Clonal hematopoiesis is associated with adverse outcomes in multiple myeloma patients undergoing transplant.”

Mouhieddine, T. H., A. S. Sperling, R. Redd, J. Park, M. Leventhal, C. J. Gibson, S. Manier, A. H. Nassar, M. Capelletti, D. Huynh, M. Bustoros, R. Sklavenitis-Pistofidis, S. Tahri, K. Hornburg, H. Dumke, M. M. Itani, C. J. Boehner, C. J. Liu, S. H. AlDubayan, B. Reardon, E. M. Van Allen, J. J. Keats, C. Stewart, S. Mehr, D. Auclair, R. L. Schlossman, N. C. Munshi, K. C. Anderson, D. P. Steensma, J. P. Laubach, P. G. Richardson, J. Ritz, B. L. Ebert, R. J. Soiffer, L. Trippa, G. Getz, D. S. Neuberg and I. M. Ghobrial
Nat Commun
, 2020.

“The JAK-STAT pathway regulates CD38 on myeloma cells in the bone marrow microenvironment: therapeutic implications.”

Ogiya, D., J. Liu, H. Ohguchi, K. Kurata, M. K. Samur, Y. T. Tai, S. Adamia, K. Ando, T. Hideshima and K. C. Anderson
Blood
, 2020.

“Minimal Residual Disease Negativity Does Not Overcome Poor Prognosis in High-Risk Multiple Myeloma: A Single-Center Retrospective Study.”

Kunacheewa, C., H. C. Lee, K. Patel, S. Thomas, B. Amini, S. Srour, Q. Bashir, Y. Nieto, M. H. Qazilbash, D. M. Weber, L. Feng, R. Z. Orlowski, P. Lin and E. E. Manasanch
Clin Lymphoma Myeloma Leuk
, 2020.

“High-risk smoldering myeloma versus early detection of multiple myeloma: Current models, goals of therapy, and clinical implications.”

Kunacheewa, C. and E. E. Manasanch
Best Pract Res Clin Haematol
, 2020.

“Preclinical evaluation of CD8+ anti-BCMA mRNA CAR T cells for treatment of multiple myeloma.”

Lin, L., S. F. Cho, L. Xing, K. Wen, Y. Li, T. Yu, P. A. Hsieh, H. Chen, M. Kurtoglu, Y. Zhang, C. Andrew Stewart, N. Munshi, K. C. Anderson and Y. T. Tai
Leukemia
, 2020.

“Phase I/II study of high dose pomalidomide with G-CSF support and dexamethasone in patients with relapsed/refractory multiple myeloma.”

Manasanch, E. E., P. Jain, W. Chen, O. Oriabure, M. Badillo, L. Feng, Z. Berkova, R. Z. Orlowski and M. Wang
Am J Hematol
, 2020.

“Phase I/Ib study of carfilzomib and panobinostat with or without dexamethasone in patients with relapsed/refractory multiple myeloma.”

Manasanch, E. E., J. J. Shah, H. C. Lee, D. M. Weber, S. K. Thomas, B. Amini, J. Olsem, B. Crumpton, A. Morphey, Z. Berkova, L. Feng and R. Z. Orlowski
Haematologica
, 2019.

“Patterns of substrate affinity, competition, and degradation kinetics underlie biological activity of thalidomide analogs.”

Sperling, A. S., M. Burgess, H. Keshishian, J. A. Gasser, S. Bhatt, M. Jan, M. Slabicki, R. S. Sellar, E. C. Fink, P. G. Miller, B. J. Liddicoat, Q. L. Sievers, R. Sharma, D. N. Adams, E. A. Olesinski, M. Fulciniti, N. D. Udeshi, E. Kuhn, A. Letai, N. C. Munshi, S. A. Carr and B. L. Ebert
Blood
, 2019.

“B cell maturation antigen (BCMA)-based immunotherapy for multiple myeloma.”

Tai, Y. T. and K. C. Anderson
Expert Opin Biol Ther
, 2019.

“Ubiquitin-activating enzyme inhibition induces an unfolded protein response and overcomes drug resistance in myeloma.”

Zhuang, J., F. Shirazi, R. K. Singh, I. Kuiatse, H. Wang, H. C. Lee, Z. Berkova, A. Berger, M. Hyer, N. Chattopadhyay, S. Syed, J. Q. Shi, J. Yu, V. Shinde, S. Tirrell, R. J. Jones, Z. Wang, R. E. Davis and R. Z. Orlowski
Blood
, 2019.