News

“Septin 9 isoform 1 (SEPT9_i1) specifically interacts with importin-alpha7 to drive hypoxia-inducible factor (HIF)-1alpha nuclear translocation.”

Tazat, K., S. Schindler, R. Depping and N. J. Mabjeesh
Cytoskeleton (Hoboken)
, 2018.

“The endoplasmic reticulum-residing chaperone BiP is short-lived and metabolized through N-terminal arginylation.”

Shim, S. M., H. R. Choi, K. W. Sung, Y. J. Lee, S. T. Kim, D. Kim, S. R. Mun, J. Hwang, H. Cha-Molstad, A. Ciechanover, B. Y. Kim and Y. T. Kwon
Sci Signal
, 2018.

“The Role of E3, E4 Ubiquitin Ligase (UBE4B) in Human Pathologies.”

Antoniou, N., N. Lagopati, D. I. Balourdas, M. Nikolaou, A. Papalampros, P. V. S. Vasileiou, V. Myrianthopoulos, A. Kotsinas, Y. Shiloh, M. Liontos and V. G. Gorgoulis
Cancers (Basel)
, 2019.

“beta-TrCP upregulates HIF-1 in prostate cancer cells.”

Cohen, M., S. Amir, M. Golan, Y. Ben-Neriah and N. J. Mabjeesh
Prostate
, 2019.

“Monitoring stress-induced autographic engulfment and degradation of the 265 proteasome in Mammalian cells.”

Cohen-Kaplan, V., I. Livneh, Y. T. Kwon and A. Ciechanover
Method in Enzymology
, 2019.

“The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage, Facilitating Double-Strand Break Repair.”

Baranes-Bachar, K., A. Levy-Barda, J. Oehler, D. A. Reid, I. Soria-Bretones, T. C. Voss, D. Chung, Y. Park, C. Liu, J. B. Yoon, W. Li, G. Dellaire, T. Misteli, P. Huertas, E. Rothenberg, K. Ramadan, Y. Ziv and Y. Shiloh
Mol Cell
, 2018.

“beta-TrCP upregulates HIF-1 in prostate cancer cells.”

Cohen, M., S. Amir, M. Golan, Y. Ben-Neriah and N. J. Mabjeesh
Prostate
, 2018.

“LATS1 and LATS2 suppress breast cancer progression by maintaining cell identity and metabolic state.”

Furth, N., I. S. Pateras, R. Rotkopf, V. Vlachou, I. Rivkin, I. Schmitt, D. Bakaev, A. Gershoni, E. Ainbinder, D. Leshkowitz, R. L. Johnson, V. G. Gorgoulis, M. Oren and Y. Aylon
Life Sci Alliance
, 2018.

“UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors.”

Jachimowicz, R. D., F. Beleggia, J. Isensee, B. B. Velpula, J. Goergens, M. A. Bustos, M. A. Doll, A. Shenoy, C. Checa-Rodriguez, J. L. Wiederstein, K. Baranes-Bachar, C. Bartenhagen, F. Hertwig, N. Teper, T. Nishi, A. Schmitt, F. Distelmaier, H. J. Ludecke, B. Albrecht, M. Kruger, B. Schumacher, T. Geiger, D. S. B. Hoon, P. Huertas, M. Fischer, T. Hucho, M. Peifer, Y. Ziv, H. C. Reinhardt, D. Wieczorek and Y. Shiloh
Cell
, 2018.

“A Systematic p53 Mutation Library Links Differential Functional Impact to Cancer Mutation Pattern and Evolutionary Conservation.”

Kotler, E., O. Shani, G. Goldfeld, M. Lotan-Pompan, O. Tarcic, A. Gershoni, T. A. Hopf, D. S. Marks, M. Oren and E. Segal
Mol Cell
, 2018.

“An oligoclonal antibody durably overcomes resistance of lung cancer to third-generation EGFR inhibitors.”

Mancini, M., H. Gal, N. Gaborit, L. Mazzeo, D. Romaniello, T. M. Salame, M. Lindzen, G. Mahlknecht, Y. Enuka, D. G. Burton, L. Roth, A. Noronha, I. Marrocco, D. Adreka, R. E. Altstadter, E. Bousquet, J. Downward, A. Maraver, V. Krizhanovsky and Y. Yarden
EMBO Mol Med
, 2018.

“Small Molecules Co-targeting CKIalpha and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models.”

Minzel, W., A. Venkatachalam, A. Fink, E. Hung, G. Brachya, I. Burstain, M. Shaham, A. Rivlin, I. Omer, A. Zinger, S. Elias, E. Winter, P. E. Erdman, R. W. Sullivan, L. Fung, F. Mercurio, D. Li, J. Vacca, N. Kaushansky, L. Shlush, M. Oren, R. Levine, E. Pikarsky, I. Snir-Alkalay and Y. Ben-Neriah
Cell
, 2018.

“Altered p53 functionality in cancer-associated fibroblasts contributes to their cancer-supporting features.”

Arandkar, S., N. Furth, Y. Elisha, N. B. Nataraj, H. van der Kuip, Y. Yarden, W. Aulitzky, I. Ulitsky, B. Geiger and M. Oren
Proc Natl Acad Sci U S A
, 2018.

“An oligoclonal antibody durably overcomes resistance of lung cancer to third-generation EGFR inhibitors.”

Mancini, M., H. Gal, N. Gaborit, L. Mazzeo, D. Romaniello, T. M. Salame, M. Lindzen, G. Mahlknecht, Y. Enuka, D. G. Burton, L. Roth, A. Noronha, I. Marrocco, D. Adreka, R. E. Altstadter, E. Bousquet, J. Downward, A. Maraver, V. Krizhanovsky and Y. Yarden
EMBO Mol Med
, 2017.

“Casein kinase 1-epsilon or 1-delta required for Wnt-mediated intestinal stem cell maintenance.”

Morgenstern, Y., U. Das Adhikari, M. Ayyash, E. Elyada, B. Toth, A. Moor, S. Itzkovitz and Y. Ben-Neriah
EMBO J
, 2017.

“The short and the long: non-coding RNAs and growth factors in cancer progression.”

Sas-Chen, A., S. Srivastava and Y. Yarden
Biochem Soc Trans
, 2017.