News

“let-7b and let-7c microRNAs promote histone H2B ubiquitylation and inhibit cell migration by targeting multiple components of the H2B deubiquitylation machinery.”

Spolverini, A., G. Fuchs, D. R. Bublik and M. Oren
Oncogene
, 2017.

“RNF20 and histone H2B ubiquitylation exert opposing effects in Basal-Like versus luminal breast cancer.”

Tarcic, O., R. Z. Granit, I. S. Pateras, H. Masury, B. Maly, Y. Zwang, Y. Yarden, V. G. Gorgoulis, E. Pikarsky, I. Ben-Porath and M. Oren
Cell Death Differ
, 2017.

“p53 is essential for DNA methylation homeostasis in naive embryonic stem cells, and its loss promotes clonal heterogeneity.”

Tovy, A., A. Spiro, R. McCarthy, Z. Shipony, Y. Aylon, K. Alton, E. Ainbinder, N. Furth, A. Tanay, M. Barton and M. Oren
Genes Dev
, 2017.

“Imaging of hypoxia-inducible factor 1alpha and septin 9 interaction by bimolecular fluorescence complementation in live cancer cells.”

Golan, M. and N. J. Mabjeesh
Oncotarget
, 2017.

“Coordinated Pulses of mRNA and of Protein Translation or Degradation Produce EGF-Induced Protein Bursts.”

Golan-Lavi, R., C. Giacomelli, G. Fuks, A. Zeisel, J. Sonntag, S. Sinha, W. Kostler, S. Wiemann, U. Korf, Y. Yarden and E. Domany
Cell Rep
, 2017.

“Learning the Roles of the Hepatic Adaptive Immune System in Hepatocellular Carcinoma-Nature’s Guide for Successful Cancer Immunotherapy.”

Heikenwalder, M. and E. Pikarsky
Semin Liver Dis
, 2017.

“Epigenetic Regulation of KPC1 Ubiquitin Ligase Effects the NF-kappaB Pathway in Melanoma.”

Iida, Y., A. Ciechanover, D. M. Marzese, K. Hata, M. Bustos, S. Ono, J. Wang, M. P. Salomon, K. Tran, S. Lam, S. C. Hsu, N. Nelson, Y. Kravtsova-Ivantsiv, G. B. Mills, M. A. Davies and D. S. Hoon
Clin Cancer Res
, 2017.

“The Ubiquitin Code in the Ubiquitin-Proteasome System and Autophagy.”

Kwon, Y. T. and A. Ciechanover
Trends Biochem Sci
, 2017.

“Cancer Cell-Autonomous Parainflammation Mimics Immune Cell Infiltration.”

Lasry, A., D. Aran, A. J. Butte and Y. Ben-Neriah
Cancer Res
, 2017.

“Identification of UBact, a ubiquitin-like protein, along with other homologous components of a conjugation system and the proteasome in different gram-negative bacteria.”

Lehmann, G., R. G. Udasin, I. Livneh and A. Ciechanover
Biochem Biophys Res Commun
, 2017.

“Monoubiquitination joins polyubiquitination as an esteemed proteasomal targeting signal.”

Livneh, I., Y. Kravtsova-Ivantsiv, O. Braten, Y. T. Kwon and A. Ciechanover
Bioessays
, 2017.

“CK1alpha ablation in keratinocytes induces p53-dependent, sunburn-protective skin hyperpigmentation.”

Chang, C. H., C. J. Kuo, T. Ito, Y. Y. Su, S. T. Jiang, M. H. Chiu, Y. H. Lin, A. Nist, M. Mernberger, T. Stiewe, S. Ito, K. Wakamatsu, Y. A. Hsueh, S. Y. Shieh, I. Snir-Alkalay and Y. Ben-Neriah
Proc Natl Acad Sci U S A
, 2017.

“Stress-induced polyubiquitination of proteasomal ubiquitin receptors targets the proteolytic complex for autophagic degradation.”

Cohen-Kaplan, V., A. Ciechanover and I. Livneh
Autophagy
, 2017.

“Epigenetic mechanisms underlie the crosstalk between growth factors and a steroid hormone.”

Enuka, Y., M. E. Feldman, A. Chowdhury, S. Srivastava, M. Lindzen, A. Sas-Chen, R. Massart, D. Cheishvili, M. J. Suderman, Y. Zaltsman, C. A. Mazza, K. Shukla, C. Korner, N. Furth, M. Lauriola, M. Oren, S. Wiemann, M. Szyf and Y. Yarden
Nucleic Acids Res
, 2017.

“Immune defects caused by mutations in the ubiquitin system.”

Etzioni, A., A. Ciechanover and E. Pikarsky
J Allergy Clin Immunol
, 2017.

“p53 shades of Hippo.”

Furth, N., Y. Aylon and M. Oren
Cell Death Differ
, 2017.